His painting, Fall of the Rebel Angels (1562) shows a departure from what was known as 'genre painting' but continues Bruegel's similarly common theme of 'good versus evil'.
The subject of this artwork is a biblical scene, taken from the Book of Revelation (12: 3-9), which was frequently depicted from the Middle Ages onwards.
The painting shows angels led by the central figure of the Archangel Michael, clad in gold armour, beating back the rebel angels from heaven.
The dragon upon which he stands may well represent the seven-headed dragon described in Revelation 12:3. The insurgents fall from the light upper-half of the painting, depicting heaven, down into the dark depths of hell, represented by the lower section.
This work clearly shows the influence on Bruegel of the artist Hieronymus Bosch who was also famous for his works on religious themes, for complex compositions and for depicting sinful characters as grotesque monsters.
Many of these monsters representing sin have an unsettling combination of human-like features as well as those recognisable as animals and Bruegel may well have been influenced by New World discoveries at this time.
Another work by Bruegel displaying a similar theme and dimensions to Fall of the Rebel Angels is Triumph of Death. Painted in the same year, it is a work which also explores themes of war, religion and mortality.
Fall of the Rebel Angels is currently held by and on display at the Royal Museum of Fine Arts of Belgium in Brussels.